On August 6th, news came from Yunnan Agricultural University——

The research team of the university has recently found the role and mechanism of tea polyphenols in promoting skin wound healing in diabetes mice by inhibiting the inflammatory target of diabetes wounds. The Journal of the American Federation of Experimental Biology published this achievement online.

It is reported that it is also the first natural monomer active ingredient found in the world to promote diabetes wound healing.

EGCG, also known as epigallocatechin gallate ester, is the main component of tea polyphenols and a catechin monomer isolated from tea. It has antibacterial, antiviral, antioxidant, anti thrombotic, anti-inflammatory, and anti-tumor effects.

Professor Sheng Jun's team conducted systematic research using biomolecular interaction technology, cell models and animal models, and found that EGCG in tea promotes the molecular mechanism of skin wound healing in diabetes mice by targeting membrane receptors.

The results showed that it can significantly inhibit the inflammatory target signaling pathway, macrophage accumulation and inflammatory response of wound skin in diabetes mice, which proves that it can directly produce effects by binding to target membrane receptors.

The research team evaluated the effect of EGCG on wound healing in diabetes.

On the wound model of diabetes mice, through continuous application, obvious wound healing can be observed in the proliferation phase of diabetes mice. The healing rate of mice treated with EGCG is about 18% higher than that of the model group, close to that of normal mice.

Further studies confirmed that EGCG combined with inflammatory targets, weakened the inflammatory reaction and inflammatory factor level of macrophages in the skin wound tissue of diabetes mice, and reduced inflammation was the main mechanism of EGCG in promoting skin wound healing of proliferative diabetes mice.

Previously, the research team took the lead in proving that the target receptor of EGCG anti-inflammatory is Notch in the world in May 2017. The anti-inflammatory effect of EGCG plays a role by inhibiting the target, and the difficulty in healing diabetes wounds is the result of long-term inflammation due to the high expression of the target.

This research provides scientific basis for people to develop natural drugs to promote wound healing of diabetes. The research team is accelerating the development of related drugs.

This article is from Science and Technology Daily